Players who test positive for COVID-19 now able to return to play in six days.
The change shifts the customary isolation period from 10 days to six, provided those players are asymptomatic and meet other testing standards.
Clubs were sent a memo by the league on Monday.
It coincided with the Centres for Disease Control and Prevention (CDC) cutting isolation restrictions for Americans who catch the coronavirus from 10 to five days.
Coronavirus numbers within the NBA has soared in recent weeks in spite of 97 per cent of players being vaccinated.
Approximately 120 current NBA players were in protocols on Monday, with the likes of Giannis Antetokounmpo, James Harden, Kevin Durant and Jayson Tatum recently forced out