Ighalo netted a brace for the Red Devils in the fifth round 3-0 win against Derby County at the Pride Park Stadium in March.
And with United manager Ole Gunnar Solskjaer ready to rest the likes of Marcus Rahsford and Anthony Martial, Ighalo could be named in the starting line-up against the Canaries.
“It’s the situation we’re in, and circumstances,” Solskjaer told a news conference on Friday.
“Of course we’re playing so many games in a short space of time, and it’s great seeing the players being in good form. I know that we’ve got so many others wanting to play as well, so there will have to be a few changes, because there’s a game again on Tuesday and then Saturday.
“That’s the pleasure of being a manager: when to give players a chance and when to give players a rest. Because we are still early on in this restart period, and it’s going to be a long period.
“Hopefully it’ll end on 21 August [the day of the Europa League final], so we’re going to have many games ahead of us. But we’re solely focused on this one now. The FA Cup is a great tournament, and we’ve started the preparations.”