Arch rivals Barcelona and Real Madrid are set to meet in Copa del Rey semi-final, the fixture will be a two legged tie.
Real Betis and Valencia will be facing off in the other last-four tie.
Barcelona are aiming to win the competition for a fifth successive year, while Real Madrid were the last winners before Barca’s run of success.
The means the two biggest clubs on Spain will play each other three times in the space of four weeks.
Real Madrid will play host to Barcelona at the Santiago Bernabeu in a La Liga game on March 2.
Barcelona will host Madrid in the first leg which will hold on February 6 while the second led in Madrid will take place February 27.
The final will be played at Benito Villamarin stadium which is the home of Real Betis in Seville on May 25.
“There’s nothing like it,” said Real Madrid director Emilio Butragueno. “We are talking about two teams with a lot of resources, with extraordinary players, and we always expect very tight games.
“We trust our players but obviously this is one of the greatest games in the world today.”
Barcelona are top of La Liga, five points clear of second-placed Atletico Madrid and 10 ahead of Real in third.