Chelsea will visit Leicester while Manchester United will host Brighton, according to the quarter-final pairings announced today.
Remarkably, four of the top Premier League’s top five were kept apart in Saturday’s draw.
Tottenham Hotspur face a trip to Sheffield Wednesday or Swansea, who need a replay after Saturday’s 0-0 draw at Hillsborough, should Mauricio Pochettino’s men overcome third-tier Rochdale on Sunday.
Manchester City continue their quest for a historic quadruple of Premier League, Champions League, FA Cup and League Cup with a fifth round trip to Wigan on Monday.
Should Pep Guardiola’s men avoid a repeat of the Latics’ shock 2013 FA Cup final victory, City will be at home to Southampton in the last eight.
The ties will be played between March 16 and 19.
Draw in full:
Sheffield Wednesday or Swansea City v Rochdale or Tottenham Hotspur
Manchester United v Brighton
Leicester City v Chelsea
Wigan or Manchester City v Southampton